Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases

Synthesis of New Substituted Tetrazole Compounds

Authors

  • Amena Alyas Ahmed Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq
  • Natiq Ghanim Ahmed Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq
  • Ahmad Khuder Ahmad Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq

DOI:

https://doi.org/10.52763/PJSIR.PHYS.SCI.63.1.2020.1.11

Keywords:

tetrazole, thiazolidinone, schiff's bases

Abstract

 

The present work involved the synthesis of compound (1) (1-amino-4-methyl-6-phenyl pyrimidine- 2-(1H)-thione). This compound reacts with different aromatic aldehyde using glacial acetic acid as catalytic on absolute ethanol to give a new series of Schiff's bases (2-7). New thiazolidine-4-one were prepared from reactions of Schiff's bases (2,3,4,7) with thioglycolic acid in absolute ethanol giving compounds (8-11). Finally the preparation of new tetrazole derivatives (12-15) by reaction of Schiff's bases (2,3,4,7) with sodium azide in THF. The structure of the synthesized compounds are confirmed by I.R., 1H-NMR and 13C-NMR spectra and some physical  data.

 

Downloads

Published

2020-03-18

How to Cite

Ahmed, A. A., Ahmed, N. G., & Ahmad, A. K. (2020). Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff’s Bases: Synthesis of New Substituted Tetrazole Compounds. Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, 63(1), 1–11. https://doi.org/10.52763/PJSIR.PHYS.SCI.63.1.2020.1.11