Schiff Bases Derived from 1-Aminoanthraquinone: A New Class of Analgesic Compounds

Schiff Bases from 1-Aminoanthraquinone


  • Ghulam Fareed Pharmaceutical Research Centre, PCSIR Laboratories Complex Karachi, Karachi-75280, Pakistan
  • Ghazala Hafeez Rizwani Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
  • Maryam Ahmed
  • Muhammad Ali Versiani
  • Nazia Fareed



schiff bases, 1-aminoanthraquinone, analgesic compound


A series of Schiff bases 1-17 were synthesised by way of a facile condensation between 1-amino-
anthraquinone with a variety of carbonyl compounds in the presence of a catalytic amount of dodeca-
tungstosilicic acid/P2O5 under solvent free conditions at room temperature. These were charachterised by
1H- and 13C-NMR, LCMS, FTIR and elemental analyses. All the compounds were screened for their
analgesic activity using hot plate thermal stimuli method at dose of 10 and 30 mg/kg. Diclofenac sodium
was used as a reference drug. All the compounds at dose of 10 and 30 mg/kg body weight showed the
significant (p<0.05) increase in latency time as compared to control (normal saline). Compound 5 showed
excellent activity after 120 min of drug administration (10 mg/kg) of body weight. Compound 10 was
found to be potent (10.48±1.19s, 11.27±1.2s and 10.24±1.9s) at dose of 30 mg/kg at 30, 60 and 120 min,
respectively when compared to the standard drug. Compound 6 (10.13±0.4s) was also found to be an
excellent analgesic compound at a dose of 30 mg/kg at 120 min. However, the studies on analgesic activity
revealed that some of the target compounds may be strong candidates as an analgesic drug.




How to Cite

Fareed, G., Rizwani, G. H., Ahmed, M., Versiani, M. A., & Fareed, N. (2017). Schiff Bases Derived from 1-Aminoanthraquinone: A New Class of Analgesic Compounds: Schiff Bases from 1-Aminoanthraquinone. Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, 60(3), 122–127.